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SYSTEMIC KETOCONAZOLE TREATMENT FOR FUSARIUM LEG ULCERS
Author(s) -
LANDAU MARINA,
SREBRNIK AVIGDOR,
WOLF RONNI,
BASHI EDNA,
BRENNER SARAH
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb02705.x
Subject(s) - ketoconazole , fusarium , medicine , fusarium oxysporum , dermatology , antifungal , mycosis , immunology , biology , botany
Fusarium oxysporum was isolated from a large foot ulcer in an otherwise healthy 69‐year‐old man. Although tissue invasion could not be proven histologically, systemic antifun‐gal treatment was administered with satisfactory response. Fusarium species are common soil‐inhabiting organisms and plant pathogens. In humans, Fusarium is considered an opportunistic agent in skin ulcers, interdigital spaces, and burned skin, but can also cause mycotic keratitis, onychomycosis, and rarely deep‐seated or disseminated infections, especially in an immunocompromised host. The distinction between skin infection and saprophytic growth, as well as optimal treatment regimens for the two types of infection, have not been clearly defined. We describe a case of leg ulcers caused by Fusarium oxysporum in a 69‐year‐old man treated successfully with oral ketoconazole. “Silent” immunologic disturbances were found in this apparently healthy patient. The case illustrates a relatively benign infection caused by Fusarium that responded to systemic antifungal drug treatment.