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RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA TREATED WITH PHENYTOIN
Author(s) -
ABAHUSSEIN ABDULAZIZ A.,
ALZAYIR AHMAD A.,
MOSTAFA WEDAD Z.,
OKORO ANEZI N.
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb01385.x
Subject(s) - medicine , phenytoin , epidermolysis bullosa , dermatology , epilepsy , psychiatry
Three patients with severe recessive dystrophic epidermolysis bullosa were treated with oral phenytoin and palliative and supportive measures for variable periods. Their progress was compared with that of three milder cases managed only with palliative and supportive measures. The phenytoin‐treated group showed marked decrease in blister count, increase in trauma tolerance, a rise in hemoglobin level, and considerable weight gain. The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa.