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The Treatment of Melasma 20% Azelaic Acid versus 4% Hydroquinone Cream
Author(s) -
Baliña Luis M.,
Graupe Klaus
Publication year - 1991
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1991.tb04362.x
Subject(s) - azelaic acid , melasma , medicine , dermatology , hydroquinone , sensitization , rosacea , acne , chemistry , organic chemistry , immunology
The efficacy of 20% azelaic acid cream and 4% hydroquinone cream, both used in conjunction with a broad‐spectrum sunscreen, against melasma was investigated in a 24‐week, double‐blind study with 329 women. Over the treatment period the azelaic acid cream yielded 65% good or excellent results: no significant treatment differences were observed with regard to overall rating, reduction In lesion size, and pigmentary intensity. Severe side effects such as allergic sensitization or exogenous ochronosis were not observed with azelaic acid.