Premium
Genetically Determined Coincidence of Kaposi Sarcoma and Psoriasis in an HIV‐Negative Patient After Prednisolone Treatment
Author(s) -
Tebbe Beate,
MayerdaSilva Augusto,
Garbe C.,
Keyserlingk HansJoachim,
Orfanos Constantin E.
Publication year - 1991
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1991.tb04222.x
Subject(s) - medicine , psoriasis , prednisolone , sarcoma , dermatology , genetic predisposition , immune system , disease , kaposi's sarcoma , immunology , pathology , human herpesvirus
We report the case of drug‐induced, acrolocalized Kaposi sarcoma (KS), arising multicentrically in both palms and soles of a male patient who has had widespread psoriasis since 12 years of age. This 59‐year‐old man, of Mediterranean origin, was HIV antibody‐negative and had received oral prednisolone treatment over 5 months for chronic obstructive lung disease (initial dose: 75 mg/d). Eight months after discontinuing oral treatment the KS nodules regressed spontaneously and finally disappeared completely without additional treatment. Light and electron microscopic investigations confirmed the diagnosis of KS, whereas laboratory tests excluded HIV infection and suggested mild immune dysfunction. The existence of HLA loci predisposing to KS and to psoriasis (A1, DR5, DR7, DR11) was characteristic for the simultaneous occurrence of these two diseases. This case report demonstrates the complex interrelationships between genetic predisposition, drugs leading to immune suppression, and the evolution of an unusual neoplasm.