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Primary Localized Amyloidosis in One Family
Author(s) -
Hashimoto Hiroyuki,
Itami Satoshi,
Kurata Sotaro,
Takayasu Susumu,
Yokota Tadaaki
Publication year - 1991
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1991.tb03488.x
Subject(s) - medicine , amyloidosis , dermatology , primary (astronomy) , pathology , physics , astronomy
Primary localized amyloidosis was found in a family. A 66‐year‐old woman had suffered from hoarseness for 18 years. A biopsy specimen from the larynx showed amyloid deposits in the submucosal connective tissue. Her 40‐year‐oid daughter noticed a subcutaneous nodule on her philtrum. Histologic examination showed the deposition of amyloid in the middle and lower dermis, which also encased the blood vessels and epidermal appendages. In both cases the amyloid deposits were positively stained with Congo red and the staining was resistant to potassium permanganate treatment. These amyloid deposits were strongly positive against the anti‐amyloid antibody of the λ light chain. These results indicate that the amyloid substance is derived from protein AL. There was no clinical or laboratory evidence of systemic amyloidosis or multiple myeloma in either patient.