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Cutaneous Thrombosis, Cerebrovascular Thrombosis, and Lupus Anticoagulant—the Sneddon Syndrome
Author(s) -
Alegre Victor A.,
Winkelmann R. K.,
Gastineau Dennis A.
Publication year - 1990
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1990.tb03755.x
Subject(s) - medicine , lupus anticoagulant , livedo reticularis , thrombosis , gangrene , thrombophlebitis , antiphospholipid syndrome , systemic lupus erythematosus , vascular disease , cerebral infarction , anticoagulant , dermatology , pathology , disease , ischemia
Ten patients with circulating lupus anticoagulant who presented with cutaneous vascular disease and Cerebrovascular disease are presented. Cutaneous manifestations were gangrene, thrombophlebitis, ulcers, and livedo reticularis. All 10 patients had cerebral infarction. The relationship between the cerebral and cutaneous vascular changes and the presence of lupus anticoagulant is supported by a common noninflammatory vascular thrombosis histologically in these patients and by the presence of similar pathologic and clinical findings in patients with the lupus anticoagulant syndrome.