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T Lymphocyte Subsets in Leprosy
Author(s) -
Ashamalla L.,
Yang S. J.,
Michel M.,
Rafla Leila
Publication year - 1989
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1989.tb02504.x
Subject(s) - leprosy , medicine , suppressor , immunology , t lymphocyte , disease , lymphocyte subsets , t cell , lymphocyte , antigen , immune system , cancer
Phenotypic analysis was done on 24 Egyptian leprosy patients and 11 healthy controls. The type of leprosy, duration of disease at the time of testing, and age were found to affect T cell subset distribution. As compared with controls, neural leprosy tended to have a decreased total T cell percentage, borderline leprosy an increased T suppressor cell percentage, and reactional borderline leprosy an increased T helper/suppressor ratio. Patients with the disease for less than 1 year had a higher mean percentage of T suppressor cells and a lower mean T helper/suppressor ratio than patients with leprosy for more than 1 year. The same was true in older (50–70 years old) versus younger (12–41 years old) patients.