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Immunopathologic Findings in Systemic Sclerosis Patients
Author(s) -
Shibeshi Dagnatchew,
Blaszczyk Maria,
JarzabekChorzelska Maria,
Jablońaska Stefania,
Chorzelski Tadeusz
Publication year - 1989
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1989.tb02435.x
Subject(s) - medicine , scleroderma (fungus) , anti nuclear antibody , iif , immunofluorescence , pathology , direct fluorescent antibody , localized scleroderma , indirect immunofluorescence , antibody , systemic scleroderma , dermoepidermal junction , dermatology , autoantibody , immunology , dermatomyositis , lichen sclerosus , dermis , inoculation
Direct immunofluorescence (DIF) of the skin biopsy specimens was performed in 62 patients with systemic scleroderma: 26 cases of acrosclerosis (group 1), 26 cases of diffuse scleroderma (group 2) and ten cases of transitional form acrosclerosis‐diffuse scleroderma (group 3). If epidermal nuclear fluorescence and lupus band test (LBT) were considered, the results were positive in 15.3% in group 1, 42.3% in group 2, and 10% in group 3. LBT was positive in 13.5% of the cases in groups 1 and 2 and negative in group 3. The immunoglobulin deposits at the dermoepidermal consisted mainly of IgM or a combination of IgG and IgM. There was no correlation between the LBT and antinuclear antibodies as detected by indirect immunofluorescence (IIF) or double immunodiffusion (DID).