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Peripheral Leukocytes in Psoriasis
Author(s) -
Liu Chenghuanc,
Ji Meirong,
Fang Xu,
Wang Huiving,
Lin Guifu
Publication year - 1988
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1988.tb02422.x
Subject(s) - lymphocytopenia , psoriasis , medicine , peripheral , peripheral blood , white blood cell , leukopenia , immunology , dermatology , lymphocyte , chemotherapy
The white blood cell (WBC) count and differential count, including the morphology and acid α‐naphthyl acetate esterase (ANAE) activity of lymphocytes, in psoriatic patients of different types, stages, and extensiveness of skin lesions were analyzed. The number of total WBC and polymorphonuclear leukocytes was markedly increased in psoriasis erythrodermica and psoriasis pustulosa. Lymphocytopenia, especially T‐lymphocytopenia, was noticed in all types of psoriasis. Antineoplastic drugs and immunosuppressants intensified the degree of T‐lymphocytopenia. This might be the cause of recurrence and more recalcitrant course of the disease. Therefore, it is considered that these drugs should not be the first choice in the treatment of psoriasis.