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Polymorphonuclear Leukocyte Functions in Psoriasis
Author(s) -
GoihmanYahr Mauricio,
Molina Tulio,
Martin Blanca San,
Pereira José,
Román Ana,
Gómez María Helena,
Villegas José Jesús
Publication year - 1988
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1988.tb02421.x
Subject(s) - medicine , psoriasis , polymorphonuclear leukocyte , immunology , dermatology , biochemistry , chemistry , in vitro
Circulating polymorphonuclear leukocyte (CPMN) functions were studied in patients with widespread psoriasis as well as in persons with chronic alcoholic liver disease (CALD), paracoccidioldomycosis, diverse granulomatous diseases, and normal individuals. We were unable to find stimulation or increase in CPMN functions in patients with psoriasis compared to normal individuals. Leukocytes, from individuals with CALD had a lowering of their metabolic activation, chemotaxis, random movement, and adherence, CPMNs from patients with paracoccidioldomycosis showed a significant deficiency in their ability to digest Paracoccidioides brasiliensis. Our results are against the concept that functions of circulating PMNs are stimulated in psoriatics.