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Transdermal Delivery of Salicylic Acid in the Treatment of Viral Papillomas
Author(s) -
Mottaz Jess H.,
Mckeever Patrick J.,
Neveaux John L.,
Zelickson Alvin S.
Publication year - 1988
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1988.tb02414.x
Subject(s) - salicylic acid , stratum corneum , transdermal , medicine , keratolytic , drug delivery , methotrexate , pharmacology , dermatology , surgery , pathology , biochemistry , chemistry , organic chemistry
Healthy adult (New Zealand, Dutch Belt, and Wild) rabbits were infected with rabbit papilloma virus (Shope variety). The resultant papillomas were treated with salicylic acid in a new transdermal drug delivery system utilizing a karaya gum glycol matrix. Biopsy samples of treated papillomas were taken at 1, 2, and 3 weeks after initiation of treatment and examined by electron microscopy. The observed changes during the course of treatment indicated that the karaya gum glycol matrix effectively released salicylic acid into the stratum corneum. Further, the rate of delivery of salicylic acid was such that the desired keratolytic activity was achieved with minimal inflammatory response.