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Atrophoderma (Pasini‐Pierini)
Author(s) -
Berman Alexander,
Berman Gary D.,
Winkelmann Richard K.
Publication year - 1988
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1988.tb00927.x
Subject(s) - dermis , pathology , papillary dermis , medicine , peripheral blood mononuclear cell , basement membrane , staining , reticular dermis , dermoepidermal junction , pathogenesis , epidermis (zoology) , antibody , anatomy , immunology , biology , biochemistry , in vitro
A patient with atrophoderma (Pasini‐Pierini) was studied. Microscopic examination showed small collections of mononuclear cells around dermal blood vessels. Electron microscopic study demonstrated macrophages and lymphocytes around vessels and between fibers in the dermis; the epidermis, dermis, collagen, and elastic fibers appeared normal. Monoclonal antibody studies of the cells in the perivascular infiltrate demonstrated cells reacting with anti‐Leu‐1 (pan‐T‐cell antibody), anti‐Leu‐3a (the helper/inducer T‐cell antibody), and OKM 1 antibody‐reacting cells (macrophages). Direct, immunofluorescent studies showed IgM and C3 staining in the small blood vessels of the papillary dermis, scattered IgM cytoids at the basement membrane, and focal fibrinogen in the mid‐dermis. Mononuclear cells in the perivascular infiltrate, similar in type and percentage concentration, have been demonstrated also in patients with anetoderma, another rare atrophic cutaneous disorder. Macrophages and T lymphocytes around papillary dermal blood vessels may play a role in the pathogenesis of atrophoderma and anetoderma.