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Effects of Nordihydroguaiaretic Acid, Phloretin, and Phloridzin on the Activity of Adenylate Cyclase, Lipoxygenase and Hexose Transport, and Growth of Cultured Keratinocytes
Author(s) -
Wilkinson David I.,
Orenberc Elaine K.
Publication year - 1987
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1987.tb02277.x
Subject(s) - phloretin , nordihydroguaiaretic acid , biochemistry , cyclase , lipoxygenase , chemistry , flavonoid , adenylate kinase , enzyme , antioxidant
Compounds related to the flavonoid group of natural products may have potential as antipsoriatic drugs. The dihydrochalcone phloretin, its glycoside derivative phloridzin. and the structurally related compound nordihydroguaiaretic acid (NDCA) were selected for study, Phloretin and NDGA strongly inhibited keratinocyte growth hut had no effect on isoproterenol‐stimulated adenylate cyclase; phloridzin had no effect on growth hut potentiated the response of the enzyme. None had any effect on phosphodiesterase. Neither phloretin or phoridzin inhibited lipoxygenase or, surprisingly, decreased deoxyglucose transport. Phloretin and NDCA should he considered antipsoriatic agents.