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Cefuroxime Axetil in the Treatment of Cutaneous Infections
Author(s) -
Parish Lawrence Charles,
Cocchetto David M.,
Werner Karen,
Jungkind Donald L.,
Witkowski Joseph
Publication year - 1987
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1987.tb00571.x
Subject(s) - cefuroxime , medicine , cefaclor , vomiting , regimen , antibacterial agent , antibiotics , nausea , anesthesia , surgery , gastroenterology , cephalosporin , microbiology and biotechnology , biology
A multicenter clinical trial was conducted in 125 out‐patients with skin and skin structure infections due to bacteria in order to compare the safety and efficacy of cefuroxime axetil and cefaclor. Patients with a median age of 32 years were randomly allocated to treatment for 10 days with one of three treatments: cefuroxime axetil 250 mg b.i.d., cefuroxime axetil 500 mg b.i.d., or cefaclor 250 mg t.i.d. Clinical evaluations of each patient were done pre‐treatment, 2 to 4 days intra‐treatment, and within 3 days post‐treatment. One patient discontinued cefuroxime axetil due to severe urticaria and one patient discontinued cefaclor due to a persistent headache and vomiting. Cefuroxime axetil was an effective antibacterial agent for treatment of common skin infections. Clinically beneficial outcome was achieved for 92% (cefuroxime axetil 250 mg b.i.d.J, 95% (cefuroxime axetil 500 mg b.i.d.J, and 97% (cefaclor 250 mg t.i.d.J of patients. Since the study failed to demonstrate a significant advantage of higher dosage, cefuroxime axetil should be prescribed in a regimen of 250 mg twice a day for patients with skin infections.