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Effects of Solcoderm
Author(s) -
Engelberg Isaac S.,
Ronnen Meyer,
Suster Saul,
SchewachMillet Miriam,
Stempler D.,
SchibiBrilliant Ginnette
Publication year - 1986
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1986.tb04714.x
Subject(s) - morphea , basal cell carcinoma , medicine , dermis , basal cell , salicylic acid , pathology , basal (medicine) , dermatology , biopsy , biology , biochemistry , insulin
The effects of treatment and depths of penetration of a 5–fluorouracil and salicylic acid preparation (Solcoderm) were studied in 24 patients treated for basal cell carcinoma with this compound. Two thirds of the patients in our study showed islands of residual tumor in the dermis following treatment, whereas total disappearance of the tumor was observed in one third. The depth of the fibrotic changes induced by the drug varied from 0.34 to 0.40 cm for the morphea type of basal cell carcinoma and from 0.52 to 0.88 cm for the conventional types. It is recommended that treatment with this compound be reserved only for superficial basal cell carcinomas and that it be avoided altogether in basal cell carcinoma of the morphea type.