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Langerhans Cells in the Dermal Infiltrate of Hyperkeratosis Lenticularis Perstans
Author(s) -
Okamoto Hiroyuki,
Endo Akiko,
Imamura Sadao
Publication year - 1986
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1986.tb04526.x
Subject(s) - dermis , pathology , langerhans cell , peripheral blood mononuclear cell , medicine , hyperkeratosis , epidermis (zoology) , pathogenesis , lesion , biology , anatomy , immunology , antigen , in vitro , biochemistry
Typical papules obtained from a patient with hyperkeratosis lenticularis perstans (HLP) were examined by light and electron microscopy. Dense cellular infiltrate, which consisted mainly of mononuclear cells, was observed in the dermis underlying the lesion. Electron microscopic studies revealed that these cells were mostly lymphocytic cells. In addition, several Langerhans cells were found in the infiltrate, some of which were apposed to the lymphocytic cells. These findings suggested that immunologic reactions via Langerhans cells might occur in HLP and further raises a possibility that Langerhans cells might be involved in the pathogenesis of HLP.