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Squamous Cell Carcinoma Arising in Porokeratosis of Mibelli
Author(s) -
James William D.,
Rodman O. G.
Publication year - 1986
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1986.tb03430.x
Subject(s) - medicine , porokeratosis , papule , dermis , lesion , anatomy , numerical digit , ankle , dermatology , pathology , arithmetic , mathematics
A 54‐year‐old woman had a linear unilateral skin lesion since age 6. Neither her parents nor her five sihlings have similar lesions. Six months prior, an ulcer developed within the abnormal skin at the flexor aspect of the right ankle. On physical examination, a linear papular dermatosis was present along the right arm from the wrist to the shoulder, along the right leg from the instep to the buttocks, and across the right flank to the umbilicus. It consisted of numerous 0.5‐to 1.0‐cm oval papules with an atrophic, sometimes red‐hrown center and a raised edge. At the flexor aspect of the right ankle was a 2‐cm ulcer (Fig. 1). The inguinal nodes were not enlarged. Results of a chest x‐ray examination and liver function tests were normal. A biopsy specimen of a typical papule revealed an atrophic epidermis bordered on two sides by coronoid lamellae (Fig. 2). Histologic sections from the ulcer edge showed a proliferation of atypical squamous cells arising from the epidermis that extended into the lower dermis (Fig. 3). A diagnosis of linear porokeratosis of Mibelli with associated sec was made. Surgical excision of the SCC with fullthickness skin grafting was done. No further malignancies have developed in the ensuing 2 years.