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Immunoprofile of Reactions in Leprosy
Author(s) -
Sehgal V. N.,
Gautam R. K.,
Sharma V. K.
Publication year - 1986
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1986.tb02233.x
Subject(s) - medicine , immunology , leprosy , antibody , erythema , immunoglobulin m , immunoglobulin g
The immunologic profile during erythema nodosum leprosum (ENL) revealed increased percentage and absolute count of B‐lymphocytes, in addition to considerably lowered levels of complement component C3. Serum immunoglobulins—IgG, IgA, and IgM—were significantly raised after subsidence of ENL, whereas upgrading reaction showed an increase of absolute count of total T lymphocytes and percentage and count of B‐lymphocytes. In addition, a raised serum IgM level was noted after regression of ENL. Downgrading reaction demonstrated a decreased percentage of early T‐lymphocytes and raised the absolute count of B‐lymphocytes. Serum IgA levels were found to be increased after amelioration of ENL.