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Bullous Pemphigoid
Author(s) -
Patterson James W.,
Ali M.,
Murray John C.,
Hazka Japan A.
Publication year - 1985
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1985.tb05416.x
Subject(s) - mycosis fungoides , medicine , dermatology , bullous pemphigoid , psoriasis , prednisone , puva therapy , methotrexate , pemphigoid , ultraviolet therapy , lymphoma , pathology , surgery , immunology , antibody
A 57‐year‐old woman with mycosis fungoides developed blisters within cutaneous plaques while receiving PUVA therapy and topical nitrogen mustard. Direct and indirect immunofluorescence studies showed the findings of bullous pemphigoid. Her bullous disease was controlled after cessation of these therapies and institution of prednisone and methotrexate. During the 5 months following completion of a course of electron‐beam therapy, she has been free of the cutaneous manifestations of both diseases. Previous instances of PUVA‐related pemphigoid have occurred in psoriatics. The role of ultraviolet light in the induction of pemphigoid is discussed, particularly with regard to its possible interaction with the altered skin of psoriasis or mycosis fungoides. Some of the rare cases of bullous mycosis fungoides might actually have represented ultraviolet‐unmasked bullous pemphigoid.