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The Absence of Dengue Virus in the Skin Lesions of Dengue Fever
Author(s) -
Anorno RichardM. de,
Botet MiguelVazquez,
Gubler, Sc.D. Duane J.,
Garcia Carlos,
Laboy Ernesto,
Espada Francisco,
Waterman Stephen H.
Publication year - 1985
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1985.tb05360.x
Subject(s) - dengue fever , dengue virus , rash , medicine , maculopapular rash , virology , skin biopsy , antibody , immunology , antigen , immune system , virus , biopsy , viral disease , globulin , pathology , dermatology
Patients with confirmed dengue infection were studied man attempt to elucidate the cause of the eruption of dengue fever. Punch biopsies of lesional skin were obtained and processed for the presence of viral antigen and immune globulins by the direct fluorescent antibody test. Another biopsy specimens and the acute sera were processed for virus isolation. Although virus isolated from the serum of two patients, isolation attempts from the biopsy specimens of all four patients were negative. fluorescent antibody studies vealed no evidence of either viral antigen or immune globulins in lesional skin. Although limited, the data suggest that the maculopapular rash of dengue fever may be caused by some mechanism other than direct viral infection of the skin or involvement of immune globulins.