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Leukocyte Chemotaxis and Pyoderma Gangrenosum
Author(s) -
Nerella Petrini,
Daniela Acampa,
Guido Modi,
Fabbri Paolo
Publication year - 1985
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1985.tb05359.x
Subject(s) - pyoderma gangrenosum , medicine , chemotaxis , dermatology , pathology , disease , receptor
Leukocyte chemotaxis (in five patient with pyoderma gangrenosum) was studied using a modification of the Boyden chamber method. In all patients the chemotactic response was significantly lower than in the controls. This abnormal chemotaxis was a result of an intrinsic neutrophil dysfunction. No significant difference was detected between the chemotactic response of leukocytes from patients with minimal or no skin involvement and those from patients with extensive lesions.