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Pseudoscleroderma and Phenylketonuria
Author(s) -
Guillet G. Y.,
Dore N.,
Hehunstre J. P.,
Maleville J.,
Battin J.
Publication year - 1983
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1983.tb02163.x
Subject(s) - phenylalanine , medicine , tyrosine , phenylketonurias , pediatrics , tryptophan , girl , amino acid , biochemistry , genetics , chemistry , biology
An infant girl with partial phenylketonuria developed pseudoscleroderma. After six years of follow up, both the neurologic and cutaneous conditions improved under a phenylalanine restricted diet. The probable roles of phenylalanine, tryptophan, tyrosine, and their metabolites may cause both conditions through possible transient hypersensitivity of cutaneous and muscular tissues.