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Percutaneous Absorption, Blood Levels, and Urinary Excretion of Resorcinol Applied Topically in Humans
Author(s) -
Yeung David,
Kantor Stuart,
Nacht Sergio,
Gans Eugene H.
Publication year - 1983
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1983.tb02149.x
Subject(s) - resorcinol , medicine , urine , glucuronide , urinary system , absorption (acoustics) , excretion , drug , pharmacology , urology , chemistry , physics , organic chemistry , acoustics
The absorption and metabolic disposition of 2% resort mot applied topically in a hydroalcoholic vehicle was determined in three human subjects. The drug penetrated the skin at a rate of 0.37μg/cm 2 /hour. After 2 weeks of bid application of 800 mg resorcinol to about 30% of body surface each subject, an average of 1.64% of the dosage was being excreted in 24‐hour urine specimens as the glucuronide or as the sulfate conjugate. There was no resorcinol in blood drawn at weeks 1, 2, 3, and 4, nor were there any abnormalities w thyroid function or blood chemistries at weeks, 2, 3, and 4. Resorcinol (2%) appears safe for topical use in humans.