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Pellagra Probably Due to Pyrazinamide: Development during Combined Chemotherapy of Tuberculosis
Author(s) -
Jørgensen Jørgen
Publication year - 1983
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1983.tb02114.x
Subject(s) - pyrazinamide , medicine , pellagra , tuberculosis , isoniazid , chemotherapy , ethambutol , pathology
Pellagra secondary to antituherculous chemotherapy can result from isoniazide therapy, as well as from pyrazinamide treatment. Because of the similarity in strucutral formulas between pyrazinamide, isoniazide, and nicotinamide, the substrate competition is the mechanism most likely involved. The patient was cured by administration of nicotinamide during continued unchanged chemotherapy of her tuberculosis.