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Prognostic Implications of Cutaneous Immunoglobulin Deposits In Systemic Lupus Erythematosus
Author(s) -
Bernstein Joel E.,
Soltani Keyoumars,
Cristancho Nersa,
Aronson Andrew J.
Publication year - 1983
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1983.tb02109.x
Subject(s) - medicine , antibody , systemic disease , immunology , lupus erythematosus , immunoglobulin m , disease , immunoglobulin g , connective tissue disease , systemic lupus erythematosus , cutaneous lupus erythematosus , systemic lupus , autoimmune disease , dermatology , immunopathology , pathology
The class of immunoglobulin (Ig) deposited at the dermal‐epidermal junction (DEI) of the skin in patients With systemic lupus erythematosus (SLE) has been proposed to have prognostic implications. The authors studied disease activity in 51 SLE patients with a positive lupus band. Patients with cutaneous IgM deposits had significantly more severe disease than those with only IgG or with mixed immunoglobulin deposits. While their data suggest an association between IgM depostis, severe disease and a poor prognosis, they urge caution in utilizing Ig deposits as a prognostic indicator.