Premium
Leprosy XII. T‐Cell Subsets in Lepromatous Leprosy
Author(s) -
Lim Soo Duk,
Woo Chung Sul,
Youn Jae Il,
Kim Youn Won,
Kim Do Il,
Fusaro Ramon M.
Publication year - 1982
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1982.tb03182.x
Subject(s) - lepromatous leprosy , leprosy , medicine , immunology , t cell , tuberculoid leprosy , t lymphocyte , rosette (schizont appearance) , cellular immunity , immune system
The authors quantitated T‐rosette‐forming cell (TRFC) and T‐cell subsets (T μ , T γ ) in the peripheral blood of twenty patients with lepromatous leprosy. The results obtained in their studies are as follows: (1) They reconfirmed the low levels of TRFC in patients with lepromatous type of leprosy; (2) T‐cell subsets, both T μ (helper) and T γ (suppressor) cells, showed lower levels in all patients with lepromatous leprosy than mean values of normal healthy controls; (3) The degree of decreased levels of T μ cells (96%) was more severe than other parameters TRFC (70%) and T γ cells (47%) in all patients with lepromatous leprosy; and (4) it may be concluded that the alteration of the T‐cell subset, T μ ‐cells, reflects a more fundamental abnormality than TRFC aberration in demonstrating the impairment of cell‐mediated immunity in patients with lepromatous leprosy.