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Complement Components in Recurrent Genital Herpes Simplex
Author(s) -
Vignale Raul A.,
Lasarvia Eduardo,
Espasandin Jose
Publication year - 1981
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1981.tb04910.x
Subject(s) - complement (music) , herpes simplex virus , medicine , complement system , genital herpes , immune system , immunology , simplex , herpesviridae , virology , virus , viral disease , biology , biochemistry , geometry , mathematics , complementation , gene , phenotype
Complement components 1,2,3,4 and total complement hemolytical activity CH 50 were studied in 39 patients with serve recurrent genital herpes simplex. The results show statistically significant and selective diminution of C 4 (P>0.001) The other components were normal. C 4 has a specific action against herpesvirus by itself or associated to some other elements over C 4 failure, local or systemic disturbances alter the homeostasis of specific and nonspecific immune system, provking a disbalance host‐virus which would explain the recurrence.