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Ketoconazole (R 41 400) in the Treatment of Dermatophyte Infections A Clinical, Mycological, and Morphological Study
Author(s) -
Degreef H.,
De Kerckhove M.,
Gevers D.,
Cutsem J.,
Den Bossche H.,
Borgers M.
Publication year - 1981
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1981.tb00401.x
Subject(s) - ketoconazole , dermatophyte , trichophyton rubrum , medicine , trichophyton , microbiology and biotechnology , dermatology , in vitro , pharmacology , antifungal , biology , biochemistry
Ketoconazole (100 mg, orally, once daily) was investigated in nine patients with extensive dermatophyte infections. After treatment ranging between one week and three months, clinical cures (healing of lesions and negative cultures) were observed in all cases. In vitro growth of Trichophyton rubrum, T. mentagrophytes, and T. verrucosum isolated from infected skin scales were completely inhibited by concentrations of ketoconazole of 10 μg/ml and above. No evidence for the development of drug resistance was obtained from regular in vitro sensitivity tests.