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Generalized Morphea with Peripheral Eosinophilia, Fasciitis and Myositis
Author(s) -
King Donald F.,
Dore Robin K.,
Gilbert Dore J.,
Gurevitch Arnold W.,
Hirose Frank M.
Publication year - 1980
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1980.tb00283.x
Subject(s) - eosinophilic fasciitis , medicine , morphea , eosinophilia , fasciitis , scleroderma (fungus) , localized scleroderma , myositis , dermatology , fascia , pathology , pathogenesis , fibrosis , biopsy , surgery , inoculation
The distinctions between eosinophilic fasciitis (Shulman's syndrome) and scleroderma may sometimes be unclear. We describe a patient with generalized morphea who also had peripheral blood eosinophilia, fibrosis and inflammation of fascia, and hyper‐globulinemia, features usually attributed to Shulman's syndrome. The latter diagnosis should be restricted to those patients whose history, clinical and laboratory findings, and response to therapy closely resemble Shulman's original description. Scleroderma and eosinophilic fasciitis may represent slightly differing aspects of the same disease spectrum, with a similar immunologic pathogenesis