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COMPARATIVE EFFECTIVENESS OF BENZOYL PEROXIDE AND TRETINOIN IN ACNE VULGARIS
Author(s) -
LYONS ROBERT E.
Publication year - 1978
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1978.tb06072.x
Subject(s) - benzoyl peroxide , acne , medicine , tretinoin , dermatology , lesion , surgery , retinoic acid , organic chemistry , chemistry , biochemistry , polymerization , gene , polymer
A controlled, randomized clinical study comparing different commercially available benzoyl peroxide gels and tretinoin cream was undertaken by four investigators using similar protocols and case report forms. Results were based on lesion‐count reduction over an 8‐week period. No significant difference in reduction of total acne lesions was detected between the benzoyl peroxide gels and tretinoin cream. However, benzoyl peroxide was significantly better (P<02) in reduction of papules and as good as tretinoin in reduction of comedones. Results of this study suggest that excessive drying and peeling are not essential in the reduction of acne lesions.