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KERATINIZATION
Author(s) -
FUKUYAMA KIMIE,
INOUE NORIO,
SUZUKI HIROYUKI,
EPSTEIN WILLIAM L.
Publication year - 1976
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1976.tb00713.x
Subject(s) - medicine , medical school , dermatology , library science , medical education , computer science
In the epidermis, the first event of this process is synthesis of DNA followed by cell division, which occurs in the basal and suprabasal layers.̂ Using light microscopy, these germinative cells can be recognized as densely stained small cells (Fig. 1). Ultrastructurally, tonofilaments and desmosomes, morphological markers of epidermal cells, are already seen in the basal cells. During mitosis, somewhat finer cytoplasmic filaments can be observed along with desmosomes and tonofilaments in the cell (Fig. 2). After mitosis, cells move out from the basal layer into the spinous layer. The cells now become larger and the intercellular bridges are more clearly seen (Fig. 4). Distinct cellular constituents which show a lamellar structure^ begin to appear, in addition to the tonofilaments and desmosomes, in spinous cells of the superficial layers (Fig. 3). In