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MEASUREMENT OF BLOOD FLOW IN SKIN WITH AN INTACT VASCULAR PEDICLE
Author(s) -
MARCUS FRED S.,
CHO SANGIN,
KOUNTZ SAMUEL L.,
POWELL MALCOLM R.
Publication year - 1976
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1976.tb00670.x
Subject(s) - medicine , blood flow , clearance , femoral artery , groin , vein , saline , artery , femoral vein , nuclear medicine , anatomy , surgery , urology
An experimental model was devised to confirm directly the validity of total skin blood flow measurement, as postulated by Sejrsen. A section of skin in the groin of the rat was prepared, which contained an intact artery and vein. Both of these were direct branches of the femoral vessels. When 133 Xe was injected intrader‐mally in saline solution, it was demonstrated that a sham isolated vascular pedicle cleared the isotope, and that the clearance was biexponential, suggesting two compartments. When the vascular pedicle was ligated, thereby removing direct blood flow to the piece of skin, the 133 Xe clearance curve was mono exponential. It is concluded that the rapid portion of the bi exponential clearance curve, as analyzed by Sejrsen, does represent the dermal vascular components of isotope clearance, and that measurement of cutaneous blood flow by this method is a valid and useful technique. Results using this technique to follow rejection in a new skin transplant model are presented.