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CLINICAL PATHOLOGIC OBSERVATIONS IN SEUDOXANTHOMA ELASTICUM
Author(s) -
ENG ANA M.,
BRYANT JAMES
Publication year - 1975
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1975.tb00148.x
Subject(s) - pseudoxanthoma elasticum , elastin , medicine , von kossa stain , calcification , pathology , stain , skin biopsy , biopsy , calcinosis , dermatology , staining , biology , biochemistry , alkaline phosphatase , enzyme
Skin biopsy material obtained from 2 patients with pseudoxanthoma elasticum associated with congenital hyperphosphatasia was compared with skin biopsy material obtained from 3 patients with pseudoxanthoma elasticum unassociated with any other disease. Clinically normal skin showed calcification of normal‐appearing elastin as the initial change in pseudoxanthoma elasticum. Elastin fibers become more ravelled as the disease progresses. A previously unreported early transient calcification of collagen was demonstrated. Other abnormal collagen forms may also be present. The Von Kossa stain appears to be the stain of choice for identifying these earliest histologic changes.