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Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog
Author(s) -
Mizuno Takuya,
Hiraoka Hiroko,
Yoshioka Chihiro,
Takeda Yoshiho,
Matsukane Yuki,
Shimoyama Natsumi,
Morimoto Masahiro,
Hayashi Toshiharu,
Okuda Masaru
Publication year - 2009
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2008.00729.x
Subject(s) - glucagonoma , mesenteric lymph nodes , medicine , lymph , pathology , spleen , glucagon , abdomen , immunohistochemistry , anatomy , hormone
An 11‐year‐old Shih Tzu presented with crusting and erythema, mainly on the abdomen and the root of the tail. Based on histopathological findings, blood examinations and necropsy findings, the condition was diagnosed as superficial necrolytic dermatitis associated with a glucagon‐secreting extrapancreatic neuroendocrine tumour. Gross necropsy revealed tumour invasion into the spleen, liver, adrenal glands and mesenteric lymph nodes. Immunohistochemical analysis of the neoplastic cells revealed that the tumour was a glucagonoma, consistent with earlier findings of persistent glucagonaemia and hypoaminoacidaemia.