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Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse
Author(s) -
Hilton Hugo,
Affolter Verena K.,
White Stephen D.
Publication year - 2008
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2008.00715.x
Subject(s) - hyperkeratosis , histopathology , dermatology , medicine , stratum corneum , keratosis , horse , acanthosis , pathology , biology , paleontology
The response to treatment with four topical preparations was evaluated in an 11‐year‐old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water‐based emollient. Response to treatment was evaluated both histologically and visually. A water‐based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre‐treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.