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Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment
Author(s) -
Welle Monika M.,
Bley Carla Rohrer,
Howard Judith,
Rüfenacht Silvia
Publication year - 2008
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2008.00694.x
Subject(s) - medicine , pathogenesis , pathology , grading (engineering) , systemic mastocytosis , mast cell , etiology , immunology , biology , disease , ecology
Abstract Mast cells (MCs) are well known for their neoplastic transformation in solitary and multiple cutaneous mast cell tumours (MCTs), as well as visceral and systemic mastocytosis. Dogs have a unique risk of developing cutaneous MCTs, and they account for 7% to 21% of all canine skin tumours. The aetiology of canine MCTs is unknown but is probably multifactorial. This article reviews up‐to‐date knowledge on the pathogenesis, the clinical presentation, the clinical prognostic factors, the diagnostic workup including clinical staging, cytological findings, histological findings and the various grading systems which have been evaluated based on morphology, the assessment of proliferation markers and other factors such as vessel density. Furthermore, detailed information about current treatment protocols for canine cutaneous MCTs is provided.