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Cornification defect in the Golden retriever: clinical, histopathological, ultrastructural and genetic characterisation
Author(s) -
Cadiergues MarieChristine,
Patel Anita,
Shearer David H.,
Fermor Ruth,
Miah Suhel,
Hendricks Anke
Publication year - 2008
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2008.00667.x
Subject(s) - ultrastructure , etiology , pathology , medicine , breed , hypopigmentation , hyperpigmentation , biology , anatomy , dermatology , genetics
Veterinarians have recognised a nonpruritic skin disease in the Golden retriever breed characterised by excessive scaling of large, variably pigmented flakes of skin in otherwise healthy dogs. This prospective case series describes clinical, histopathological, ultrastructural and genetic features of this cornification defect in 17 affected dogs. The condition affects young dogs of either sex and is characterised by symmetrical, predominantly ventro‐lateral scaling and hyperpigmentation of the trunk. Histopathological and ultrastructural changes of the stratum corneum are suggestive of delayed degradation of corneodesmosomes. A genetic aetiology is proposed and a single‐trait autosomal recessive mode of inheritance discussed.