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Pemphigus foliaceus‐like drug reaction in a 3‐month‐old crossbreed dog treated for juvenile cellulitis
Author(s) -
Horvath Christa,
Neuber Ariane,
Litschauer Barbara
Publication year - 2007
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2007.00620.x
Subject(s) - pemphigus foliaceus , medicine , dermatology , cellulitis , drug , juvenile , surgery , immunology , biology , pharmacology , antibody , autoantibody , genetics
Two weeks after administration of routine vaccinations, a 3‐month‐old, male crossbreed dog developed cutaneous lesions that were clinically and histopathologically consistent with a diagnosis of juvenile cellulitis. The patient was treated with systemic antibacterial, antibacterial ophthalmic ointment and nonsteroidal anti‐inflammatory drugs. Within 1 week, new skin lesions that were clinically, histopathologically and immunohistochemically consistent with pemphigus foliaceus developed. The latter completely resolved following drug withdrawal, suggesting a pemphigus foliaceus‐like drug reaction. However, the initial lesions persisted and required glucocorticoid therapy to effect resolution. To the authors’ knowledge, this is the first reported case of a puppy developing juvenile cellulitis followed by a pemphigus foliaceus‐like reaction shortly thereafter, in response to drug therapy.