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A review of autoimmune skin diseases in domestic animals: I – Superficial pemphigus
Author(s) -
Olivry Thierry
Publication year - 2006
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2006.00540.x
Subject(s) - pemphigus foliaceus , pemphigus , acantholysis , pemphigus vulgaris , medicine , paraneoplastic pemphigus , dermatology , autoimmune disease , immunopathology , pathology , disease , immunology , autoantibody , antibody
In humans, the pemphigus denomination encompasses a group of autoimmune blistering skin diseases with intraepidermal separation resulting from cell–cell detachment by acantholysis. Entities are classified based on the level of blistering in the epidermis, and both superficial (pemphigus foliaceus, IgA pemphigus) and deep (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) variants are recognized. In domestic animals, subsets of pemphigus have been recognized since the mid‐1970s, and the disease classification resembles that used for human patients. This article reviews up‐to‐date knowledge on the epidemiology, clinical signs, histopathology, immunopathology and treatment outcome of superficial pemphigus in domestic animals. Detailed information on canine, feline, equine and caprine pemphigus foliaceus, canine and feline pemphigus erythematosus and canine panepidermal pustular pemphigus is provided.