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Isotretinoin in the treatment of multiple benign pilomatrixomas in a mixed‐breed dog
Author(s) -
TOMA STEFANO,
NOLI CHIARA
Publication year - 2005
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2005.00470.x
Subject(s) - isotretinoin , breed , medicine , adverse effect , regimen , blood count , biopsy , skin biopsy , retinoid , dermatology , complete blood count , surgery , zoology , retinoic acid , chemistry , biology , biochemistry , gene , acne
An 18‐month‐old cross‐breed dog developed multiple skin nodules, which over 8 months had increased in size and number. Biopsy samples were submitted for histopathological examination and revealed multiple benign pilomatrixomas. The dog was treated with 1 mg kg −1 isotretinoin daily, which led to a stabilization of the size and number of the lesions. Attempts to lower the dosage to an every other day regimen led to an increase in the nodules’ size and number. Monthly complete blood count and chemistry tests and Schirmer tear tests were performed to monitor any adverse effects of the retinoid treatment. No adverse effects were noted. To the authors’ knowledge, this is the first report of multiple pilomatrixomas arising in a young dog and successfully controlled with oral retinoids.