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Cutaneous extraskeletal mesenchymal chondrosarcoma in a cat
Author(s) -
ROMANUCCI MARIARITA,
BONGIOVANNI LAURA,
PETRIZZI LUCIO,
SALDA LEONARDO DELLA
Publication year - 2005
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2005.00429.x
Subject(s) - pathology , mesenchymal stem cell , vimentin , chondrosarcoma , medicine , immunohistochemistry , endochondral ossification , ossification , neoplasm , necrosis , subcutaneous tissue , anatomy , cartilage
A 4‐year‐old, male cat was presented with a fixed, subcutaneous mass in the lumbosacral region. A histopathological examination revealed a well‐defined but nonencapsulated neoplasm characterized by a proliferation of predominantly spindle cells, with high mitotic activity. Interspersed between these cells were single cellular elements with chondroid differentiation. Large areas of cartilaginous tissue with foci of endochondral ossification, necrosis and myxoid tissue were also observed within the neoplastic parenchyma. A diagnosis of extraskeletal mesenchymal chondrosarcoma was made based on the histological pattern – characterized by the coexistence of cartilaginous islands and undifferentiated mesenchymal cells, results of Alcian blue staining at various pH, immunohistochemical reactivity against vimentin and S‐100, and the absence of skeletal involvement or other primary tumour sites. Clinical history of the cat excluded traumas, vaccinations or other types of subcutaneous inoculation. Six months on from surgical treatment, neither recurrence nor metastases have been detected.