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Junctional epidermolysis bullosa in two domestic shorthair kittens
Author(s) -
ALHAIDARI ZEINEB,
OLIVRY THIERRY,
SPADAFORA ANNE,
THOMAS RANDALL C.,
PERRIN CHRISTOPHE,
MENEGUZZI GUERRINO,
ORTONNE JEAN PAUL
Publication year - 2005
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2005.00420.x
Subject(s) - junctional epidermolysis bullosa (veterinary medicine) , lamina densa , lamina lucida , epidermolysis bullosa , immunoperoxidase , histopathology , cats , medicine , pathology , direct fluorescent antibody , dermatology , laminin , anatomy , biology , ultrastructure , antibody , immunology , monoclonal antibody , basal lamina , genetics , cell
This article describes two cases of junctional epidermolysis bullosa in nonrelated kittens. Both cats exhibited pinnal erosions, oral ulcerations and severe onychomadesis. Histopathology, electron microscopy and/or indirect immunoperoxidase revealed subepidermal clefting, with the lamina densa remaining attached to the floor of the vesicles. Indirect immunofluorescence revealed reduced staining for laminin‐5 γ2 subunit in case 1 and β3 subunit in case 2.