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Pale sulphonated shale oil exhibits antimicrobial and tissue repairing effects in wound healing
Author(s) -
Gayko G.
Publication year - 2004
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2004.411_62.x
Subject(s) - antimicrobial , antiseptic , wound healing , medicine , staphylococcus aureus , essential oil , oil shale , surgery , microbiology and biotechnology , chemistry , food science , pathology , biology , bacteria , genetics , paleontology
A proliferation‐promoting effect on keratinocytes as well as increased generation of the wound‐healing factor PDGFαβ could be observed in vitro in the presence of diluted aqueous solutions of pale sulphonated shale oil. Concomitantly, pale sulphonated shale oil exhibits antimicrobial properties against all infectious agents that are relevant in wound infection and delayed healing, including methicillin‐resistant Staphylococcus aureus . Since most antiseptic substances and local antibiotics cause delayed wound healing, pale sulphonated shale oil has special significance in this field. For this reason, a project for development and approval of a medicinal veterinary product for wound healing in horses according to European Community procedures has been started. No approved product for horses is currently available in Europe. In a dose‐finding study, a hydrogel formulation containing 20% pale sulphonated shale oil as the active pharmaceutical ingredient was found to be most efficient in wound healing. In a study on target‐species tolerance in horses, this formulation proved to be well tolerated in long‐term topical application. Case studies from the clinical efficacy trial show a broad profile of action of pale sulfonated shale oil. Funding: ICHTHYOL‐Gesellschaft.