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P‐66
Disseminated histiocytic sarcoma in a dog receiving long‐term immunosuppressive therapy
Author(s) -
Kawabata A.,
AokiOta M.,
Sekiguchi M.,
Momoi Y.,
Iwaski T.
Publication year - 2004
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2004.00414_66.x
Subject(s) - medicine , histiocytic sarcoma , prednisolone , dermatology , sarcoma , nodule (geology) , surgery , histiocyte , pathology , paleontology , biology
A 4‐year‐old female Labrador retriever that had been receiving prednisolone for over 8 months because of severe pruritus developed iatrogenic Cushing's syndrome and was referred to our hospital. After complete withdrawal of prednisolone, atopic dermatitis was diagnosed, based on clinical signs, history, an elimination diet test and an intradermal test. Immunotherapy was started, but it was discontinued 3 months later due to lack of improvement. Several drugs, including prednisolone and cyclosporine, were used in an attempt to control the pruritus, and amitriptyline was added for psychogenic treatment. When the dog was 5.5 years old, dome‐shaped and nonpainful nodules were detected on the digits, neck and shoulder. Three months after the first nodule was detected, nodules had developed all over the body, and most were ulcerated. The nodules were examined histopathologically and the diagnosis was disseminated histiocytic sarcoma. As disseminated histiocytic sarcoma has a reportedly poor prognosis, only antibiotic therapy in addition to continuous amitriptyline and prednisolone administration was pursued. The dog died 6 months after the first nodule was detected. The dog received immunosuppressive agents long‐term to control severe pruritus due to atopic dermatitis. There is a possibility that a long‐term immunocompromised state may lead to the development of neoplasms, such as disseminated histiocytic sarcoma. Funding: Self‐funded.