Premium
P‐64
Cutaneous epitheliotropic lymphoma in a dog: treatment with oral pentoxifylline
Author(s) -
Manigot G. A.
Publication year - 2004
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2004.00414_64.x
Subject(s) - medicine , pentoxifylline , dermatology , skin biopsy , vasculitis , lymphoma , prednisone , biopsy , surgery , pathology , disease
A 9‐year‐old intact female Shih Tzu‐mix dog with a generalized form of cutaneous epitheliotropic lymphoma with vasculitis lesions was treated with oral pentoxifylline (200 mg twice daily) after failure to control the process with prednisone (2 mg/kg). The dog showed signs of internal lymph node involvement and hepatic invasion. Lesions included all three typically described stages at the same time with a 1‐year period of a highly pruritic erythematous dermatitis. At the time of consultation, the dog showed erythroderma, mild scaling, ulcerated nodules, crusted plaques, hypopigmentation of the planum nasale, lips and eyelids, and vasculitis of the footpads. Biopsy samples and cytology were diagnostic for cutaneous epitheliotropic lymphoma. Therapy consisted of prednisolone at a dosage of 2 mg/kg, but it failed to control the progression of the disease. Vasculitis lesions increased in number and area, thus pentoxifylline (200 mg twice daily) was administered. The use of pentoxifylline resulted in a marked improvement of the skin condition, decreasing the erythroderma, healing the vasculitis lesions and controlling the pruritus. The dog died 2 months after the initial clinical, cytological and histopathological diagnosis, because of respiratory complications. More research needs to be done on dogs with terminal cases of cutaneous epitheliotropic lymphoma that fail to be controlled with the usual therapy. Those dogs might benefit from the use of pentoxifylline. Funding: Self‐funded.