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Equine congenital papilloma: pathological findings and results of papillomavirus immunohistochemistry in five cases
Author(s) -
WHITE KELLY S.,
FUJI REI.,
VALENTINE BETH A.,
BILDFELL ROBERT J.
Publication year - 2004
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2004.00395.x
Subject(s) - pathology , immunohistochemistry , papilloma , acanthosis , lesion , papillomatosis , medicine , koilocyte , bovine papillomavirus , biology , hyperkeratosis , cancer , cervical cancer , cervical intraepithelial neoplasia , genome , gene , biochemistry
Congenital cutaneous papillomas were identified in five foals. Age at diagnosis ranged from 305 days’ gestation to 2 days of age. Breeds were thoroughbred (2), standard‐bred (1), warmblood (1) and paint (1). Two were female, one was male and the gender of two cases was not specified. Masses were pedunculated with a roughened, wart‐like (verrucous) or a smoother, cauliflower‐like surface. Masses occurred as single lesions on the forelimb, lip and face, or as multiple lesions on the trunk. Histological features included relatively uniform epidermal papillary hyperplasia with variable melanin pigment within basal layers and vacuolization of keratinocytes in all layers, but with no evidence of nuclear or cytoplasmic changes (koilocytes) characteristic of viral infection. One case showed epidermal proliferation with proliferation of pilosebaceous units. Results of immunohistochemical studies for the detection of papillomavirus antigens were negative in all cases. These results suggest that equine congenital papilloma may be a hamartomatous lesion (epidermal nevus) and not a viral‐induced growth.