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Cutaneous vascular malformation in a guinea pig ( Cavia porcellus )
Author(s) -
Osofsky Anna,
De Cock Hilde E. V.,
Tell Lisa A.,
Norris Aimee J.,
White Stephen D.
Publication year - 2004
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.2004.00364.x
Subject(s) - cavia , guinea pig , immunohistochemistry , pathology , vascular malformation , lesion , histology , anatomy , medicine , population , biology , surgery , environmental health
A skin lesion classified as a vascular malformation is reported in a young‐adult, female guinea pig. The physical examination revealed a 3 × 2‐cm irregularly shaped violaceous plaque located on the left caudal flank. The surface of the plaque was ulcerated and bled intermittently, resulting in fatal blood loss. On histology the mass consisted of variably sized vascular spaces filled with red blood cells and variable amounts of extramedullary haematopoietic cells, lined by well‐differentiated endothelial cells often surrounded by one layer of spindle‐shaped cells. Based on immunohistochemistry, the spindle cell population was confirmed to be smooth muscle cells and no proliferation of endothelial cells was found with the Ki67 proliferation marker. Histological and immunohistochemical findings were consistent with a vascular malformation. Classification of vascular malformations and potential treatments are discussed. To the authors’ knowledge, this is the first reported case of a cutaneous vascular lesion in a guinea pig.