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Marked Acantholysis Associated with Dermatophytosis due to Trichophyton equinum in Two Horses
Author(s) -
SCOTT DANNY W.
Publication year - 1994
Publication title -
veterinary dermatology
Language(s) - Spanish
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/j.1365-3164.1994.tb00021.x
Subject(s) - dermatology , medicine , dermatophyte , trichophyton , veterinary medicine , antifungal
Resumen— Dos caballos adultos manifestaron un cuadro prurítico y de dolor asociado con una dermatitis generalizada de evolución rápida y consistente en la presencia de pápulas, pústulas y costras. El examen microscópico de extensiones citológicas a partir del exudado purulento reveló la presencia de numerosos queratinocitos acantoliticos, neutrófilos no degenerados y ausencia de microorganismos, lo que sugirió un diagnóstico de pénfigo foliáceo. Las biopsias de piel mostraron dermatofitosis, marcada acantolisis y creció Trichophyton equinum en cultivos fúngicos. Las lesiones en ambos animales se resolvieron tras administrar una terapia tópica con sulfuro de cal. Postulamos que los encimas proteoliticos liberados por las cepas de Trichophyton equinum aisladas fueron los responsables del alto grado de acantolisis detectada citológica e histológicamente. [Scott D. W. Marked acantholysis associated with dermatophytosis due to Trichophyton equinum in two horses (Acantolisis marcade en associación con dermatofitosis por Trichophyton equinum en dos caballos). Abstract— Two adult horses developed a rapidly progressive, generalized, painful, pruritic, papular, pustular, and crusting dermatitis. Microscopic examination of direct smears made from purulent exudate revealed numerous acantholytic keratinocytes, nondegenerate neutrophils, and no microorganisms, suggesting a diagnosis of pemphigus foliaceus. Skin biopsies revealed dermatophytosis with prominent acantholysis, and fungal cultures were positive for Trichophyton equinum. The lesions in both horses resolved in association with topical applications of lime sulfur. It is hypothesized that proteolytic enzymes produced by the strains of T. equinum isolated were responsible for the prominent acantholysis seen cytologically and histologically.