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Dengue en viajeros: Aplicabilidad de los sistemas de la OMS del 2009 y de 1975‐1997 para la clasificación de la fiebre del dengue
Author(s) -
Wieten Rosanne W.,
Vlietstra Wytze,
Goorhuis Abraham,
van Vugt Michèle,
Hodiamont Caspar J.,
Leenstra Tjalling,
de Vries Peter J.,
Janssen Saskia,
van Thiel Pieter P.,
Stijnis Kees,
Grobusch Martin P.
Publication year - 2012
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2012.03020.x
Subject(s) - dengue fever , medicine , disease , warning signs , cohort , diabetes mellitus , pediatrics , intensive care medicine , immunology , transport engineering , engineering , endocrinology
Objectives The aim of this study was to assess the applicability and benefits of the new WHO dengue fever guidelines in clinical practice, for returning travellers. Methods We compared differences in specificity and sensitivity between the old and the new guidelines for diagnosing dengue and assessed the usefulness in predicting the clinical course of the disease. Also, we investigated whether hypertension, diabetes or allergies, ethnicity or high age influenced the course of disease. Results In our setting, the old classification, compared with the new, had a marginally higher sensitivity for diagnosing dengue. The new classification had a slightly higher specificity and was less rigid. Patients with dengue who had warning signs as postulated in the new classification were admitted more often than those who had no warning signs (RR, 8.09 [1.80–35.48]). We did not find ethnicity, age, hypertension, diabetes mellitus or allergies to be predictive of the clinical course. Conclusions In our cohort of returned travellers, the new classification system did not differ in sensitivity and specificity from the old system to a clinically relevant degree. The guidelines did not improve identification of severe disease.