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Comunicación corta : El recuento total de linfocitos es un marcador sustituto fiable del conteo de células CD4 tras el primer año de terapia antirretroviral: datos de un estudio de cohortes en Indonesia
Author(s) -
de Jong Marrigje A.,
Wisaksana Rudi,
Meijerink Hinta,
Indrati Agnes,
van de Ven Andre J. A. M.,
Alisjahbana Bachti,
van Crevel Reinout
Publication year - 2012
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2012.02961.x
Subject(s) - medicine , cohort , lymphocyte , antiretroviral therapy , surrogate endpoint , cohort study , human immunodeficiency virus (hiv) , immunology , viral load
Many studies have evaluated the total lymphocyte count (TLC) as a cheap surrogate marker for CD4 cells in HIV‐infected patients not receiving antiretroviral therapy (ART). We assessed whether TLC can replace CD4 cell counts in evaluating the immunological response to ART. In a cohort of patients in Indonesia TLC, if measured after at least 1‐year ART, correctly identified patients with <200 CD4 cells, and reliably excluded immunological failure, obviating the need for CD4 cell measurement in 43% of patients.